ABSTRACT
Objective: To determine the frequency of prediabetes in patients with non-alcoholic fatty liver disease and to compare the mean values of cholesterol, triglycerides, low density lipoproteins and high density lipoproteins in patients of non-alcoholic fatty liver disease with and without prediabetes
Study Design: Cross sectional study
Place and Duration of Study: This study was conducted at Medical Outpatient Department, Sharif Medical City Hospital, Lahore from 30[th] December 20 1 3 to 29[th] June 20 14
Materials and Methods: Three hundred twenty five patients with ultrasonic diagnosis of NAFLD were included
All the patients with other causes like alcohol, viral hepatitis, toxins and drugs were excluded. All patients were screened by Glucose tolerance test [GTT] and if post GTT, blood sugar level came out greater than mg/dl, it was labeled prediabetes. Lipid profile was compared in both groups
Results: Frequency of the pre-Diabetes is quite high in our population with nonalcoholic fatty liver disease i.e.82.2% and means values of cholesterol, triglyceride low density of lipoprotein and high density lipoprotein in patients of non-alcoholic fatty liver disease are equally distributed patients with and without pre-diabetes
These mean values are, mean value of cholesterols patients with pre-diabetes was 1.86.8 +/- 2.3 mg/dl while without pre- diabetes it was 193.4 +/- 40.8 mg/dl while mean triglyceride level in patients with pre-diabetes was 180.5 +/- 37.2 mg/dl while without pre-diabetes patients it was with 180.7 +/- 40.4 mg/dl. Similarly the mean LDL level was 157.8 +/- 19.4 mg/dl and with pre-diabetes and 156.8 +/- 19.8 mg/dl in patients of NAFLD without pre-diabetes
Conclusion: It is concluded that frequency of prediabetes and dyslipidemia is quite high so we should screen all patients of NAFLD for glucose intolerance